The explosion took place at St Mark's Cathedral, main Coptic Christian cathedral, in Abbassyia district of central Cairo around 10:00 am when the prayers were on, according to a statement by the ministry of health.
Two powerful blasts triggered by Islamic State in two churches packed with worshippers celebrating Palm Sunday in Egypt's Tanta and Alexandria cities.
The Egyptian government has ordered military special forces to assist the police in securing vital state facilities across the country.